Microfluidic paper chip

Microfluidic paper chips using paper as a substrate instead of silicon, glass, polymers and other materials, through a variety of processing technology, processed on paper with a certain structure of the pro / hydrophobic microchannel network and related analytical devices to build "microfluidic Control chip ", also known as paper chips.

        Paper analysis chip is an emerging paper analysis technology platform, which is widely used in medical diagnosis, food safety monitoring and environmental monitoring because of its advantages of simple manufacture, low cost and good biocompatibility. The paper material has the unique and attractive qualities of separation and support in the test device: its composition is inert cellulose, rich in origin, cheap, renewable, easy to handle, recyclable, Easy to use and transport, easy to chemical modification, has good stability and good biocompatibility. Combined with modern printing technology, microfluidic devices can be easily prepared for separation, analysis and detection, making them an excellent material for testing.

Paper chip material selection requirements:

        Paper chips, the choice of paper material is critical, to consider a number of factors, such as: sufficient mechanical bearing capacity; immersion in the water phase without significant deformation and disassembly; suitable hydrophilic and hydrophilic easy adsorption and fixation to form a clear test area, and To avoid excessive spillage; Do not degrade biological analytes or other detection reagents; The surface should be uniform in order to reproduce, modify, and generate signals; Reduce the coffee-ring stain effects that are common in conventional methods; Consider the package with the composite material matching effect and so on.

WENHAO shares two ways to make paper chips: the first is the use of physical or chemical means, so that the whole piece of paper is evenly covered by the hydrophobic material, and then through a certain technology for all the hydrophobized areas further pro Water treatment; the other method is a one-time part of the filter paper hydrophilic or hydrophobic treatment, the formation of a direct channel with the hydrophobic phase of the micro-channel.

Paper chip uses and applications:

Paper chips are widely used in food safety, pesticide residues and other fields to be tested qualitative or quantitative testing. Auxiliary detection methods are luminosity detection method, fluorescence method, chemiluminescence, electrochemiluminescence and electrochemical detection method. Among them, photometric detection and electrochemical methods are currently the most widely used.

Wenhao shares of the chip part of the test cases are as follows:

The application of paper chips: Detection of heavy metal ions in liquid samples, enabling simultaneous detection of multiple ions; Detection of total arsenic, total selenium, nitrite, melamine, clenbuterol and pesticide residues in foods; Detection of urine glucose, Protein, pH, uric acid, urobilinogen, bilirubin, ketone body, ascorbic acid and other tests.